Abstract
Background
OPN is a multifunctional glycophosphoprotein originally described as a secreted protein
from malignant epithelial cells. This study focused on the clinical significance of
preoperative serum level of OPN in NSCLC patients who underwent a complete resection.
Patients and Methods
The serum OPN level was assayed in 244 patients who underwent a complete resection
of NSCLC by commercially available sandwich enzyme-linked immunosorbent assay kits.
The patients were considered as a higher group, when the serum OPN levels exceeded
81.3 ng/mL.
Results
The patients included 166 male and 78 female subjects. The histologic types included
172 adenocarcinomas, 49 squamous cell carcinomas, and 23 other types of carcinoma.
The serum level of OPN in male patients (92.6 ng/mL) was significantly higher than
that of female patients (76.9 ng/mL). The OPN level of squamous cell carcinoma was
significantly higher than that of adenocarcinoma. The OPN level was significantly
elevated in patients with the pleural invasion or microvascular invasion than those
without the invasion. The 5-year survival rate after surgery in the lower OPN group
(82.0%) was a significant favorable prognosis than that in the higher OPN group (63.7%)
(P < .0001). The 5-year survival rates in the lower OPN group at stage I NSCLC (88.1%)
was significantly better than that in the higher OPN group (80.5%) (P = .0321).
Conclusion
The preoperative serum OPN level was a useful predictor of an unfavorable prognosis,
and it was found to be an independent prognostic determinant of outcome in patients
who underwent surgery for NSCLC.
Keywords
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Article info
Publication history
Published online: November 02, 2012
Accepted:
September 28,
2012
Received in revised form:
September 28,
2012
Received:
July 25,
2012
Epub: Nov 1, 2012Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
