Abstract
Purpose
There is insufficient data regarding the incidence rate of secondary lung cancer among
Hodgkin lymphoma (HL) survivors and the predisposing factors.
Methods
We analyzed the data from the cohort of patients who had HL between 1973 and 2015
using the Surveillance Epidemiology and End Results database (SEER). Data on patient's
age, gender, year of diagnosis with HL, Ann-Arbor stage, Histology, racial groups,
date of last follow-up, date of death, and treatment modalities were collected.
Results
We identified a total of 56,856 patients with HL; of those, 862 had secondary lung
cancer, with an incidence rate of 157 (95%CI: 147-168) per 100,000 person-years. The
median overall survival from time of HL diagnosis for those with secondary lung cancer
was 12.1 years (95% CI: 10.7-13) compared to 27.1 years (95% CI: 26.5-27.6) for those
who did not develop lung cancer (log-rank P-value of <.01). After propensity score weighting, radiation therapy was associated
with a higher risk of secondary lung cancer (hazard ratio (HR): 1.23, 95% CI: 1.002-1.55)
with a P-value of 0.048. Older age at the time of HL diagnosis and male gender were associated
with higher risk, with an HR of 1.07 (95% CI 1.062-1.073) and an HR of 1.602 (95%
CI 1.33-1.94), respectively. Furthermore, chemotherapy increased the risk only among
older age groups.
Conclusion
Older age at the time of HL diagnosis, male gender, radiation therapy, and chemotherapy
only among older age groups were associated with higher risk for secondary lung cancer,
with 50% of the cases occurring within 9.1 years following HL diagnosis.
Keywords
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Article info
Publication history
Published online: August 06, 2022
Accepted:
August 3,
2022
Received in revised form:
July 21,
2022
Received:
February 25,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
