Targeted therapy for lung cancer with paraneoplastic disseminated intravascular coagulation: A case report and pooled analysis

Published:September 25, 2022DOI:

      Clinical Practice Points

      • Thrombocytopenia in advanced non-small cell lung cancer (NSCLC) patients may indicate disseminated intravascular coagulation (DIC).
      • Paraneoplastic DIC is associated with adenocarcinoma and may cause thrombosis, bleeding, and thrombocytopenia.
      • We described a patient with EGFR-mutant adenocarcinoma who experienced severe thrombocytopenia due to DIC.
      • Osimertinib resulted in a rapid resolution of DIC and thrombocytopenia in this patient.
      • Among 17 cases of pulmonary adenocarcinoma with DIC treated with targeted therapy, the estimated 1-year survival rate was 69%.
      • For patients with advanced NSCLC, testing for actionable biomarkers is important, even in the presence of DIC.


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