Clinical Practice Points
- •Plasma-based next-generation sequencing can potentially identify additional driver alterations in patients with NSCLC compared to single-gene testing for EGFR, ALK and ROS1; this can be relevant when there is limited tissue for molecular profiling or if tissue biopsy is not feasible.
- •The identification of driver alterations in plasma helps NSCLC patients to be treated with matched targeted therapy, which eventually might lead to better outcomes.
- •Further studies exploring the cost-effectiveness of complementary liquid biopsy in addition to tissue genotyping are warranted, as well as novel strategies such as a tissue-sparing, plasma-first approach.
- •Timely and equitable access to targeted therapies will also be critical to translate research in precision medicine into improved patient care.
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Published online: February 08, 2023
Accepted: February 2, 2023
Received in revised form: February 2, 2023
Received: August 5, 2022
Publication stageIn Press Journal Pre-Proof
© 2023 Published by Elsevier Inc.